Successful Pregnancy and Delivery After AOA

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Other: Calcium ionophore; Other: Strontium chloride (SrCl2)

• Registration Number: NCT01595815
• Lead Sponsor: Maria Fertility Hospital

Brief Summary

Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05
• Primary Completion: 2011-09
• Study First Submitted: 2012-05-09
• Study First Submitted QC: 2012-05-09
• Study First Posted: 2012-05-10
• Status Verified: 2014-01
• Study Completion: 2014-04
• Last Update Submitted: 2025-05-06
• Last Update Posted: 2025-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Fertilization rate was less than 30% after conventional ICSI.
• Fertilization rate was less than 50% after ICSI with calcium ionophore.
• Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles

Exclusion Criteria

• Fertilization rate was more than 30% after conventional ICSI
• Fertilization rate was more than 50% after ICSI with calcium ionophore.
• Successful pregnancy and delivery after ICSI in previous cycles

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conventional ICSI	Calcium ionophore	The couple showed complete fertilization failure after ICSI.
Conventional ICSI	Strontium chloride (SrCl2)	The couple showed complete fertilization failure after ICSI.
Convention ICSI	Calcium ionophore	The couple showed a low fertilization rates after ICSI.
Convention ICSI	Strontium chloride (SrCl2)	The couple showed a low fertilization rates after ICSI.

Primary Outcome Measures

Name	Time	Method
Fertilization rate	18 hours

Secondary Outcome Measures

Name	Time	Method
Embryo quality	3 Days
Pregnancy and Implantation rates	2 months
Assessment of Infant health care	birth and at 3, 6, 12, 24, 36, 60, and 72 months	This assessment is according to the standard set by the National Health Insurance Service (NHIS) in Korea.

Trial Locations

Locations (1)

Maria Fertility Hospital; 🇰🇷 Seoul, Korea, Republic of