The Effect of Artificial Oocyte Activation on Blastocysts Rate in Patients with Low Fertilization Rate
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Blastocyst rate
研究概览
简要总结
Studies reported that calcium signal deficiency or insufficiency during oocyte activation are related with embryo arrest and blastocyst quality. The utilization of Artificial Oocyte Activation (AOA) is safe and does not increase birth defects, cognition, language and motor skills. AOA is the first line of treatment in patients with globozoospermia (round headed spermatozoa). Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists and comprises about 10-15% of patients undergoing controlled ovarian hyperstimulation. The absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. The European Society of Human and REproduction (ESHRE) recommends AOA in cases with failed fertilization/ low fertilization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with poor or no blastocyst development in their primary cycle
- •Group 1 - second cycle using AOA following the poor blastocyst development cycle
- •Group 2 - second cycle without AOA following the poor development cycle
排除标准
- •All cycles who do not have repeat cycles following the poor blastocyst development cycle
结局指标
主要结局
Blastocyst rate
时间窗: 5 days after oocyte fertilization
Likelihood of an oocyte fertilized to blastocyst stage
次要结局
未报告次要终点