Artificial Oocyte Activation Comparing Tow Different Agents
Overview
- Phase
- Not Applicable
- Intervention
- Ca Ionophore
- Conditions
- Oocyte Fertilization
- Sponsor
- Ibn Sina Hospital
- Enrollment
- 450
- Locations
- 3
- Primary Endpoint
- Pregnancy rate ( % )
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Comparing the efficacy of tow factors for artificial Oocyte Activation for poor quality Oocytes and Teratozoospermia patients.
Detailed Description
The IVF outcome had been varied widely with a good portion of total fertilization failure even after the most advanced procedure for this group of patient Intracytoplasmic Sperm Injection, many factors that had been tested for assisting the failed group of patient to be fertilized artificially like Ca Ionophore, Strontium Chloride and others but we decide to compare the clinically proven factors for the efficacy and safety in a well randomized clinical trial and monitor the embryogenesis and pregnancy within the 2 groups.
Investigators
Muhammad Fawzy
IVF Lab Director
Ibn Sina Hospital
Eligibility Criteria
Inclusion Criteria
- •previous fertilization failure
- •poor quality Oocytes
- •poor sperms
Exclusion Criteria
- •normal patients
Arms & Interventions
Ca Ionophore group
Artificial Oocyte activation with Ca Ionophore for 20 min after Intracytoplasmic Sperm Injection
Intervention: Ca Ionophore
Ca Ionophore group
Artificial Oocyte activation with Ca Ionophore for 20 min after Intracytoplasmic Sperm Injection
Intervention: Artificial Oocyte activation
Strontium Chloride group
Artificial Oocyte activation with Strontium Chloride for 60 min after Intracytoplasmic Sperm Injection
Intervention: Artificial Oocyte activation
Strontium Chloride group
Artificial Oocyte activation with Strontium Chloride for 60 min after Intracytoplasmic Sperm Injection
Intervention: Strontium Chloride
Outcomes
Primary Outcomes
Pregnancy rate ( % )
Time Frame: 9 months
Secondary Outcomes
- Blastocyst rate ( % )(9 months)