Impact of Non Digestible Carbohydrate on Production of Phenolic Acids From Strawberry Juice
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Phenolic acids bioavailability
研究概览
简要总结
This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. We hypothesize that combination of dietary polyphenolics and non-digestible carbohydrates (NDC) will increase the production of phenolic acids by bacteria in the human colon and these will be detected in urine. Participants will attend for three arms in a randomised order: Strawberry juice (a high polyphenol food), Inulin (NDC) or Mixture of strawberry juice and inulin.
详细描述
Polyphenol rich plant foods have been associated with several health benefits but their bioavailability is generally low. The majority of plant polyphenols are poorly absorbed in the small intestine and enter the colon where the colonic microbiota metabolise them to release a range of phenolic acids, which are now thought to be the main bioactive components related to the reduction in disease risk. Very little is known about the impact of other constituents of the diet on the metabolism and bacterial catabolism of these polyphenols. The colonic microbiota are key agents in the release of the bioactive molecules from polyphenols but also ferment non-digestible carbohydrates (NDC) such as dietary fibre to short chain fatty acids. It is likely that there are key interactions in the colonic bacteria metabolism of fibre and phenolics. We hypothesize that combination of polyphenolics and non-digestible carbohydrates (NDC) will increase the urinary output of bioactive phenolic acids.
This study will enable a better understanding of how to deliver combinations of ingredients and nutrients to achieve maximum nutritional value and health benefits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Self-reported healthy adults
排除标准
- •Antibiotic use within the last 3 months, identified gastro-intestinal diseases, on prescribed medication other than the contraceptive pill, individuals who are pregnant or breastfeeding. Individuals who have been diagnosed as anaemic, as well as those who are allergic to any food, or paracetamol.
研究组 & 干预措施
Strawberry juice with inulin
One dose of 300 g of strawberry with 10 g of inulin will be given to subjects in the form of juice
干预措施: Strawberry juice with Inulin (Dietary Supplement)
Strawberry juice
One dose of 300 g of strawberry juice will be given to subjects in the form of juice
干预措施: Strawberry Juice (Dietary Supplement)
Inulin
One dose of 10 g of inulin will be given to subjects in the form of a drink
干预措施: Inulin (Dietary Supplement)
结局指标
主要结局
Phenolic acids bioavailability
时间窗: 0-24 hrs
Urine excretion of phenolic acids
次要结局
- Gastric emptying time(0-6 hrs)
- Urolithin bioavailability(0-24 hrs)
- Glycaemic and appetite hormones measurements by ELISA(0-8 hrs)
- Mouth to caecum transit time(0-8 hrs)
研究者
Christine Edwards
Professor
University of Glasgow
