Adherence to Mediterranean diet can reduce the risk of obesity in people with genetic predisposition to obesity

Not Applicable

Completed

• Conditions: Nutritional, Metabolic, Endocrine; Obesity

• Registration Number: ISRCTN15898185
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

2002 Results article in https://www.ncbi.nlm.nih.gov/pubmed/12643001 results (phase one) 2009 Results article in https://www.ncbi.nlm.nih.gov/pubmed/19166627 results (phase two) in 2017 Results article in https://pubmed.ncbi.nlm.nih.gov/28954439/ (added 20/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-02-15
• Study Start: 2017-08-02
• Last Update Posted: 3 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

1. Age =18 years
2. Both genders
3. Participating in baseline and follow-up examinations of Tehran Lipid and Glucose Study
4. BMI=30 for cases, BMI=18.5 and <25 for controls.
5. Not pregnant or lactating women
6. Not history of weight loss or gain >5 kg in the last 6 months
7. Not taking drugs that affect weight
8. Not under or over-reporters of energy intake
9. DNA purification in the range of 1.7<A260/A280<2

Exclusion Criteria

1. Individuals with a history of weight loss or gain >5 kg in the last 6 months
2. Pregnant and lactating
3. Taken drugs that affect weight
4. Cases/controls lacking DNA purification in the range of 1.75. Reported energy intakes divided by the predicted energy intake did not qualify for the ±3SD range

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Weight is measured using the digital scales at baseline and each follow-up examination (every three years)<br>2. Height is measured using a tape measure at baseline and each follow-up examination (every three years)<br>3. Waist circumference is measured using the upstretched tape meter at baseline and each follow-up examination (every three years)<br>4. Hip circumference is measured using the upstretched tape meter at baseline and each follow-up examination (every three years)

Secondary Outcome Measures

Name	Time	Method
1. BMI (body mass index) is calculated by dividing weight in kilograms on height in meters squared baseline (kg/m2) at baseline and each follow-up examination (every three years)<br>2. WHR (waist to hip ratio) is calculated by dividing waist on hip circumferences at baseline and each follow-up examination (every three years)<br>3. Obesity was defined as a BMI =30 kg/m2 <br>4. BMI between 18.5 and 24.9 classified a person as having a normal weight<br>5. Waist circumference >95 cm for both genders was considered as indicators of abdominal obesity<br>6. WHR >0.8 in men and >0.9 in women, was considered as indicators of abdominal obesity