Serum magnesium levels and recurrent wheeze in children between 2 months to 3 years of age
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Mean difference in serum magnesium levels in children with recurrent wheeze and those without recurrent wheeze aged 2 months to 3 years.
研究概览
简要总结
Recurrent wheezing is a prevalent respiratory problem that impacts a significant proportion of children especially younger than 3 years due to bronchospasm, mucosal edema, and accumulation of excessive secretions causing a greater obstructive effect on their smaller, more compliant airways. Magnesium has been shown to relax bronchial smooth muscle in vitro, however the correlation between serum magnesium levels and the severity of wheezing remains controversial. Serum magnesium levels can have implications in prevention and management of recurrent wheeze in this vulnerable population.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2.00 Month(s) 至 3.00 Year(s)（—）
- 性别
- All
入选标准
- •Children between 2 months to 3 years of age presenting with recurrent wheeze ( more than 2 episodes since birth).
排除标准
- •Children with known causes of recurrent wheeze (eg congenital heart disease, chronic lung disease, tuberculosis, GERD, Immunodeficiency, and neurological disorders) 2) Children who have received nutritional supplements containing magnesium in the last 7 months.
结局指标
主要结局
Mean difference in serum magnesium levels in children with recurrent wheeze and those without recurrent wheeze aged 2 months to 3 years.
时间窗: At baseline
次要结局
- 1) Correlation between serum magnesium levels & the frequency of episodes(2) Association of respiratory distress severity criteria with magnesium levels in children aged 2 months to 3 years with recurrent wheeze.)
研究者
Shaily Singh
Maulana Azad Medical College