Pre treatment with Magnesium sulphate Before Non-depolarizing Muscle Relaxants; Effect on speed of onset and recovery using Neuromuscular Monitoring
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To determine the effect of Magnesium Sulphate pre-treatment on onset and duration recovery of neuromuscular blockade
研究概览
简要总结
Laryngoscopy and tracheal intubation trigger sympathetic surges
Magnesium sulphate blunts catecholamine release and is widely used for hemodynamic control and as an anticonvulsant
At the neuromuscular junction Magnesium Sulphate inhibits presynaptic acetylcholine release and can potentiate non depolarizing neuromuscular blockers
Magnesium sulphate decreases the need for anesthesia shortens the time needed for propofol to induce anaesthesia and decreases the overall amount of postoperative analgesics used without having any negative effects on the mother or the unborn child
The potential of magnesium sulphate to enhance neuromuscular blockade has been suggested but requires confirmation through direct neuromuscular monitoring studies
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients undergoing elective surgeries under GA 2.ASA grade 1and 2 3.Informed consent 4.BMI 18-28 kg/m2 5.All non cardiac surgery.
排除标准
- •1.on sedatives /hypnotic pre operatively 2.Allergy to study drug 3.Psychiatric illness.
结局指标
主要结局
To determine the effect of Magnesium Sulphate pre-treatment on onset and duration recovery of neuromuscular blockade
时间窗: vitals will be monitored at before induction, just after intubation, 5min,30min,60min and before reversal and after extubation and 5 min after extubation
次要结局
未报告次要终点
研究者
Syed Noor Mohammed
Sapthagiri Institute Of Medical Sciences And Research Centre