Human Circadian Sensitivity to Very Short Light Pulses

Not Applicable

Completed

• Conditions: Circadian Rhythm Disorders
• Interventions: Other: Ocular light or darkness exposure

• Registration Number: NCT01330992
• Lead Sponsor: Brigham and Women's Hospital

Brief Summary

The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms, melatonin suppression, heart rate, pupillary reflexes, cognitive performance, alertness and sleep. The results of the proposed work can be used to make predictions about the effects of light, to make recommendations involving exposure to or avoidance of light, and to design environmental lighting, resulting in improved health and alertness and decreased errors and accidents.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2011-04-01
• Study First Submitted QC: 2011-04-06
• Study First Posted: 2011-04-07
• Status Verified: 2011-08
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Last Update Submitted: 2011-08-19
• Last Update Posted: 2011-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Healthy volunteers

Exclusion Criteria

• No medications
• No eye disease
• No sleep disorders
• No psychiatric disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Ocular Light or Dark Exposure	Ocular light or darkness exposure	Ocular Light or Dark Exposure

Primary Outcome Measures

Name	Time	Method
Circadian Phase (hours)	Before and after intervention (day 1)	Circadian phase (hours) measured before and after intervention

Trial Locations

Locations (1)

Brigham and Women's Hospital; 🇺🇸 Boston, Massachusetts, United States