Human Circadian Sensitivity to Very Short Light Pulses
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 400
- Locations
- 2
- Primary Endpoint
- Circadian Phase (hours)
Study Overview
Brief Summary
The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms, melatonin suppression, heart rate, pupillary reflexes, cognitive performance, alertness and sleep. The results of the proposed work can be used to make predictions about the effects of light, to make recommendations involving exposure to or avoidance of light, and to design environmental lighting, resulting in improved health and alertness and decreased errors and accidents.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy volunteers
Exclusion Criteria
- •No medications
- •No eye disease
- •No sleep disorders
- •No psychiatric disorders
Outcomes
Primary Outcomes
Circadian Phase (hours)
Time Frame: Before and after intervention (day 1)
Circadian phase (hours) measured before and after intervention
Secondary Outcomes
No secondary outcomes reported
Investigators
Elizabeth B. Klerman
Associate Professor, Associate Physician
Brigham and Women's Hospital