The effect of vasopressors on resting energy expenditure in critically ill mechanically ventilated patients measured via indirect calorimetry

Not Applicable

• Conditions: Circulatory System; Respiratory

• Registration Number: PACTR202010510238366
• Lead Sponsor: Kasr alainy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-07-03
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients included in the study were aged between 18 and 60 years and who were clinically suspected of having severe sepsis defined by the criteria of the American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference; (12) and received noradrenaline vasopressor therapy.

Exclusion Criteria

Exclusion criteria included patients aged less than 18 years and more than 60-years-old, pregnant patients, patients who required chest tube insertion, patients who received an FiO2 more than 0.6 and PEEP more than 14 cm H2O, patients with body temperature more than 38oC or less than 36 oC, acute hepatitis or severe liver disease (Child-Pugh class C), patients on haemodialysis and patients with known endocrine dysfunction as myxedema, thyrotoxicosis, Addison’s disease and Cushing syndrome.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
primary outcome of the study was the correlation between the change in vasopressor concentration and the REE measured by indirect calorimetry

Secondary Outcome Measures

Name	Time	Method
The secondary outcome was the correlation between REE measured by indirect calorimetry and REE calculated by Harris Benedict equation