Prediction of radiation induced lung damage based on dose distribution and tumour location. A pilot study.
- Conditions
- Lung cancer (both NSCLC and SCLC)10038666
- Registration Number
- NL-OMON33481
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
. Age > 18 years
. WHO PS 0-2
. Stage IIIA/IIIB Non Small Cell Lung Cancer (NSCLC). Planned for conventionally fractionated radiotherapy with or without concomitant chemotherapy, 51-60 Gy.
. Limited disease Small Cell Lung Cancer, i.e. tumor confined to hemithorax without evidence of distant metastases or malignant pleural effusion. Planned for conventionally fractionated (chemo)radiotherapy, 45 Gy.
. Adequate pulmonary function
. Life expectancy of at least 6 months
.. Before patient registration, informed consent must be given
Exclusion Criteria
. WHO PS=3
. Life expectancy less than 6 months
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Density changes measured with serial CT-scans scored using the newly developed<br /><br>quantification method.</p><br>
- Secondary Outcome Measures
Name Time Method <p>. The regional dependency of structural lung damage (tumor location)<br /><br>. The relationship between lung density changes and dose distribution<br /><br>. The dynamics of structural lung damage (density changes) in time</p><br>