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Clinical Trials/NCT01044316
NCT01044316
Completed
Phase 3

A Phase III Observer-Blind, Randomized, Controlled, Single-Coordinating Center Pediatric Study in China Comparing Two Doses of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Vaccine Versus a Tetanus Toxoid-Conjugated Vaccine Using a Local Dosing Regimen in Infants

Novartis Vaccines0 sites670 target enrollmentApril 2010

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
Haemophilus Influenzae Type b (Hib) Infection
Sponsor
Novartis Vaccines
Enrollment
670
Primary Endpoint
Anti-PRP antibody levels at day 31 post last vaccination
Status
Completed
Last Updated
14 years ago

Overview

Brief Summary

This study will evaluate the safety and efficacy of two doses of two commercially available vaccines used to prevent Haemophilus influenzae type b infections in children 6-12 months of age.

Registry
clinicaltrials.gov
Start Date
April 2010
End Date
December 2010
Last Updated
14 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Novartis Vaccines
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Infants 6-12 months of age.

Exclusion Criteria

  • Prior Hib vaccine administration.
  • History of serious reaction(s) following vaccination.
  • Any vaccination within 14 days of study vaccination.
  • Known or suspected immune impairment.
  • For additional entry criteria please refer to the protocol.

Outcomes

Primary Outcomes

Anti-PRP antibody levels at day 31 post last vaccination

Time Frame: 30 days after last vaccination

Secondary Outcomes

  • Solicited local and systemic reactions, AEs, and SAEs(30 days post last vaccination)

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