Interesterified fats: Health effects of commercially relevant palmitic versus stearic acid rich interesterified fats

Completed

• Conditions: lipoprotein metabolism; Metabolisme; risk factors for cardiovascular disease

• Registration Number: NL-OMON48329
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

- Apparently healthy men and women
- Non-smoking
- Age: 35-65 yrs
- Having a general practitioner
- Signed informed consent
- Agreeing to be informed about medically relevant personal test-results by a
physician
- For the subgroup (Maastricht only): No contra-indication for MRI measurements

Exclusion Criteria

- Having a medical condition which might impact study measurements
- Use of over-the-counter and prescribed medication, which may interfere with
study measurements
- Use of food supplements or plant-sterol/stanol-enriched foods or supplements
in the three months prior to the screening and/or during the study;
- Reported alcohol consumption * 21 units/week;
- Reported weight loss or gain of 3 kg or more during a period of 2 months
prior to screening
- Reported dietary habits: medically prescribed diet, allergy/intolerance to
test products that will be provided during the study
- Blood donation in the past 3 months
- Drug abuse
- Reported participation in another nutritional or biomedical trial 3 months
prior to screening
- Serum lipids: treatment recommended according to the *Multidisciplinaire
richtlijn Cardiovasculair risicomanagement*
- Body mass index < 20 kg/m2 or > 35 kg/m2

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the difference in the total to HDL-cholesterol ratio<br /><br>as measured at the end of the intervention periods. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints include the postprandial lipidemic and glycaemic effects<br /><br>after chronic exposure to these fats.</p><br>