NCT00824772已完成不适用
Evaluation of Pharmacogenetic Factors Contributing to Dose Requirement of Fentanyl for Postoperative Pain Control: Genetic Polymorphisms of OPRM1, ABCB1, CYP3A4 and CYP3A5
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 204
- 试验地点
- 1
- 主要终点
- Postoperative Cumulative Fentanyl Consumption
研究概览
简要总结
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors affecting the variable requirements of fentanyl during postoperative period.
详细描述
The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing total abdominal hysterectomy (TAH) or laparoscopy assisted vaginal hysterectomy (LAVH) under general anesthesia
- •Patients who want to use intravenous patient controlled analgesia (PCA) after surgery
- •ASA physical status class I, II
排除标准
- •history of drug addiction
- •opioid medication within 12 hours before surgery
- •previous history of opioid medication for 3 months
- •neurologic disorder
- •cardiac disorder
- •hepatic disease
- •renal disease
- •respiratory disease such as COPD, asthma
- •sleep apnea
- •BMI > 30
- •psycotic disorder
结局指标
主要结局
Postoperative Cumulative Fentanyl Consumption
时间窗: 24 hr after surgery
次要结局
- Postoperative Cumulative Fentanyl Consumption(48hr after surgery)
研究者
Kye-Min Kim
Associate professor, Department of Anesthesiolgy & Pain Medicine, Inje University
Inje University
研究点 (1)
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