NCT00824772
Completed
Not Applicable
Evaluation of Pharmacogenetic Factors Contributing to Dose Requirement of Fentanyl for Postoperative Pain Control: Genetic Polymorphisms of OPRM1, ABCB1, CYP3A4 and CYP3A5
ConditionsPain, Postoperative
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain, Postoperative
- Sponsor
- Inje University
- Enrollment
- 204
- Locations
- 1
- Primary Endpoint
- Postoperative Cumulative Fentanyl Consumption
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors affecting the variable requirements of fentanyl during postoperative period.
Detailed Description
The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.
Investigators
Kye-Min Kim
Associate professor, Department of Anesthesiolgy & Pain Medicine, Inje University
Inje University
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing total abdominal hysterectomy (TAH) or laparoscopy assisted vaginal hysterectomy (LAVH) under general anesthesia
- •Patients who want to use intravenous patient controlled analgesia (PCA) after surgery
- •ASA physical status class I, II
Exclusion Criteria
- •history of drug addiction
- •opioid medication within 12 hours before surgery
- •previous history of opioid medication for 3 months
- •neurologic disorder
- •cardiac disorder
- •hepatic disease
- •renal disease
- •respiratory disease such as COPD, asthma
- •sleep apnea
- •BMI \> 30
Outcomes
Primary Outcomes
Postoperative Cumulative Fentanyl Consumption
Time Frame: 24 hr after surgery
Secondary Outcomes
- Postoperative Cumulative Fentanyl Consumption(48hr after surgery)
Study Sites (1)
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