ongitudinal Characterization of Intrahepatic Immune Responses and Gene Expression Profiles in Patients with Viral Hepatitis. An investigator initiated single centre study. - Longitudinal characterization of viral hepatitis patients.

Stichting Leveronderzoek0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•* Diagnosed with chronic HCV or chronic HBV
•* Hepatitis C viral RNA detectable in case of chronic HCV infection or HBsAg positive for over 6 months in case of chronic HBV infection.
•* Non-cirrhotic compensated liver disease.
•* Age * 18 years and * 70 years.
•* Written informed consent.

•* Extensive bridging fibrosis indicated by histology (gold standard), imaging, transient elastography or clinical decompensated cirrhosis (Child-Pugh Grade B or C).
•* Hepatic imaging (ultrasound, CT or MRI) with evidence of hepatocellular carcinoma.
•* Females who are pregnant or breast-feeding.
•* History or other evidence of severe illness, malignancy or any other condition which would make the patient, in the opinion of the investigators, unsuitable for the study.
•* Received prolonged therapy with immunomodulatory agents (e.g. corticosteroids) or biologics (e.g. monoclonal antibody, interferon) within 6 months of screening.

发起方

Stichting Leveronderzoek