Processing of the hepatic and systemic immune responses in patients with metabolic syndrome and/or non-alcoholic fatty liver disease

Not Applicable

• Conditions: K75.8; E66.0; Other specified inflammatory liver diseases; Obesity due to excess calories

• Registration Number: DRKS00014596
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

all patients with confirmed diagnosis of metabolic syndrome, age = 18 years, which undergo a bariatric-surgical operation for a clinical indication

Exclusion Criteria

all patients with a relevant liver disease except NADLD or NASH, other life-threatening conditions, pregnant women, alcohol abuse (>30g for men, >20g for women), known drug abuse or participation in drug substitution program, weight loss > 5% 6 months prior to study inclusion, inability to consent

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Definition of the composition of the T cell immune response in the liver, the fatty tissue and the peripheral blood in patients with metabolic syndrome and/or NAFLD. Correlation of these results with the incident of the disease, the disease activity and the progress of the disease.

Secondary Outcome Measures

Name	Time	Method
one defined.