Efficacy of Ketamine in Post Anesthesia Recovery Room

Completed

• Conditions: Pain, Postoperative; Ketamine Adverse Reaction; Pain, Refractory; Pain, Acute; Pain, Intractable
• Interventions: Drug: Ketamine

• Registration Number: NCT04701008
• Lead Sponsor: University of Alberta

Brief Summary

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

Detailed Description

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.

After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.

The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.

Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Study Timeline

• Study Start: 2020-09-01
• Study First Submitted: 2021-01-05
• Study First Submitted QC: 2021-01-05
• Study First Posted: 2021-01-08
• Primary Completion: 2021-05-28
• Study Completion: 2021-05-28
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-25
• Last Update Posted: 2022-07-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 143

Inclusion Criteria

Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:

• age ≥ 18
• significant pain despite narcotics used in post-anesthesia care unit
• ketamine ordered by attending anesthesiologist

Exclusion Criteria

• Patient refusal to receive ketamine
• Patients undergoing cardiac surgery
• Patients who received no narcotics
• Contra-indication to receiving ketamine (determined by attending anesthesiologist)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with significative post-operative pain despite	Ketamine	Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.

Primary Outcome Measures

Name	Time	Method
Reduction in pain score after ketamine use in PACU	in the immediate post-operative period in recovery room	The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.

Secondary Outcome Measures

Name	Time	Method
Incidence of side effects after ketamine use	in the immediate post-operative period in recovery room

Trial Locations

Locations (1)

University of Alberta Hospital; 🇨🇦 Edmonton, Alberta, Canada