The effects of a vitamin K-enriched dairy product on vitamin K-status and vascular health

Completed

Conditions: preventie van hart-en vaatziekten
niet van toepassing

Registration Number: NL-OMON34582

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Apparently healthy men and postmenopausal women between 45 and 65 years old
Subjects of normal body weight and height according to BMI between 23 and 30 kg/m2
Subjects of Caucasian race
Subject has given written consent to take part in the study
Low vitamin K-status

Exclusion Criteria

Subjects with hypertension
Subjects with hypercholesterolemia
Subjects with (a history of) metabolic or gastrointestinal disease
Subjects presenting chronic degenerative and/or inflammatory disease
Subjects with (a history) of diabetes mellitus
Abuse of drugs and/or alcohol
Subjects receiving corticostero*d treatment
Subjects using oral anticoagulants and subjects with clotting disorders
Subjects using blood pressure lowering medication
Subjects using cholesterol-lowering medication
Subjects using vitamin K containing multivitamins or vitamin K supplements
Subjects consuming high amounts of vitamin K-containing food products
Subjects with cow*s milk allergy and lactose intolerance

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameters measured during the study are the undercarboxylated and<br /><br>carboxylated forms of the vitamin K-dependent proteins matrix-gla protein and<br /><br>osteocalcin. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are the levels of V-CAM, ICAM-1, E-selectin,<br /><br>SAA, sPLA-2, CRP, vWF, VEGF, IL-6, TNF-a, total cholesterol, triglycerides, and<br /><br>the lipoproteins HDL-cholesterol and LDL-cholesterol. </p><br>