Phase II Study of Stereotactic Body Radiotherapy (SBRT) and Chemotherapy for Unresectable Cholangiocarcinoma Followed by Liver Transplantation
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Progression-free Survival at 12 Months
研究概览
简要总结
The purpose of this study is to determine progression-free survival at 12 months for stereotactic body radiotherapy (SBRT) and chemotherapy for unresectable hilar cholangiocarcinoma (CCA).
详细描述
Investigators hope to learn more about neoadjuvant SBRT and chemotherapy for unresectable CCA, and if SBRT followed by chemotherapy can lead to successful liver transplantation. This knowledge is important for this patient group as this disease is a highly lethal malignancy that often presents as unresectable, however surgery or transplantation are the only curative options.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of cholangiocarcinoma by any of the below:
- •Positive transcatheter biopsy or brush cytology
- •CA 19-9 ≥ 100mg/mL with a malignant-appearing stricture on cholangiography
- •Biliary ploidy by fluorescent in situ hybridization with a malignant stricture on cholangiography
- •Liver tumors not to exceed 8 cm in greatest axial dimension (800 cc of uninvolved liver)
- •Unresectable tumor above cystic duct
- •Hepatic lesion in patients for whom surgical resection is not possible or would not result in an opportunity for cure by any of the below:
- •Bilateral segmental ductal extension
- •Encasement of the main portal vein
- •Unilateral segmental ductal extension with contralateral vascular encasement
- •Unilateral atrophy with either contralateral segmental ductal or vascular (hepatic artery, portal vein) involvement
- •Ascites is allowed if the Model for End-Stage Liver Disease (MELD) score is <15[1]
- •Age > 18 years old
- •Eastern Clinical Oncology Group performance status 0, 1 or 2 (Appendix 1)
- •Lab values within 2 wks prior to randomization:
- •See STUDY SCHEMA for specific blood count inclusion criteria: ANC ≥ 500 x 109/L (≥ 1500/mm3), Platelets ≥ 5 x 109/L (≥ 50,000/mm3), Hgb ≥ 9g/dL
- •Adequate liver function: Total bilirubin ≤1.5 x upper limit of normal (ULN); ALT and/or AST & alkaline phosphatase ≤ 5 x ULN.
- •Adequate biliary drainage, with no evidence of active uncontrolled infection (patients on antibiotics are eligible).
- •See STUDY SCHEMA for specific renal function inclusion criteria: Adequate renal function with a calculated GFR ≥ 40 ml/min. If the calculated GFR is below 40 ml/min a 24 hour urine creatinine clearance can be used.
- •Albumin > 2.5 mg/dL
- •INR ≤ 1.5
- •Life expectancy > 6 months
- •Capable of giving written informed consent
排除标准
- •Prior radiotherapy to the upper abdomen
- •Contraindication to receiving radiotherapy
- •Prior chemotherapy
- •Prior biliary resection or attempted resection
- •Prior transperitoneal biopsy
- •Large esophageal varices without band ligation
- •Active GI bleed or within 2 weeks of study enrollment
- •Ascites refractory to medical therapy or shunting
- •Active/unresolved biliary tract obstruction
- •Presence of multifocal, lymphatic, or extrahepatic metastases
- •Participation in another concurrent treatment protocol
- •If history of other primary cancer, subject eligible only if she or he has:
- •Curatively resected non-melanomatous skin cancer
- •Curatively treated cervical carcinoma in situ
- •Other primary solid tumor curatively treated with no known active disease present and no treatment administered for the last 3 years
- •Any evidence of severe or uncontrolled systemic diseases or laboratory finding that in the view of the investigator makes it undesirable for the patient to participate in the trial
- •Any psychiatric or other disorder (eg brain metastases) likely to impact on informed consent
- •Pregnancy or breast-feeding
- •While not excluded, patients with significant impaired hearing must be made aware of potential ototoxicity and may choose not to be included. If included, baseline audiograms are recommended and, in those given cisplatin, should be followed by repeat audiograms prior to cycle 2.
研究组 & 干预措施
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: Capecitabine (Drug)
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: Stereotactic Body Radiotherapy (Procedure)
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: Gemcitabine (Drug)
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: Cisplatin (Drug)
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: Carboplatin (Drug)
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: 5FU (Drug)
SBRT, Chemo and Liver Transplantation
The patients received Stereotactic Body Radiotherapy and Chemotherapy followed by a liver transplantation. The chemo could be any combination of the following: Gemcitabine, Cisplatin, Carboplatin, Capecitabine and 5FU
干预措施: Liver transplantation (Procedure)
结局指标
主要结局
Progression-free Survival at 12 Months
时间窗: 12 months
Progression free survival is defined to be the time to progression of disease or death.
次要结局
- Liver Transplant Rate(12 months)
- Pathologic Complete Response Rate(12 months)
- Serum CA 19-9 Levels(12 months)
- Overall Survival at 12 Months(12 months)
- Freedom From Local Progression at 12 Months(12 months)
- Liver Transplant Conversion Rate(12 months)
- Median Time to Overall Survival(18 months)
研究者
Daniel T. Chang
Assistant Professor
Stanford University