Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.

Capecitabine is indicated as treatment for a variety of cancer types. For colorectal cancer, capecitabine is indicated as a single agent or a component of a combination chemotherapy regiment for the adjuvant treatment of stage III colon cancer and treatment unresectable or metastatic colorectal cancer. It can also be used as a part of a combination chemotherapy perioperative treatment of adult locally advanced rectal cancer. For breast cancer, capecitabine is indicated for advanced or metastatic breast cancer as a single agent if an anthracycline- or taxane-containing chemotherapy is not indicated or as a regimen with docetaxel after disease progression on prior anthracycline-containing chemotherapy. For gastric, esophageal, or gastroesophageal junction (GEJ) cancer, capecitabine is indicated as a component of a combination chemotherapy treatment for the treatment of adult unresectable or metastatic gastric, esophageal, or GEJ cancer or adult HER2-overexpressing metastatic gastric or GEJ adenocarcinoma who have not received prior treatment for metastatic disease. Finally, for pancreatic cancer, capecitabine is indicated as adjuvant treatment for adult pancreatic adenocarcinoma as a component of a combination chemotherapy regimen.

• Advanced or Metastatic Breast Cancer
• Carcinoma of Gallbladder
• Cholangiocarcinoma
• Hepatocellular Carcinoma
• Locally Advanced Rectal Cancer (LARC)
• Metastatic Adenocarcinoma of the Gastroesophageal Junction
• Metastatic Gastric Cancers
• Metastatic Neuroendocrine Tumors
• Pancreatic Adenocarcinoma
• Pancreatic Cancer, Advanced or Metastatic
• Platinum-resistant Epithelial Ovarian Cancer
• Refractory Fallopian Tube Carcinoma
• Stage III Colon Cancer
• Unresectable or Metastatic Colorectal Cancer
• Metastatic pancreatic endocrine carcinoma
• Refractory peritoneal cancer
• Refractory, metastatic Colorectal carcinoma
• Unresectable, metastatic Esophageal Cancer
• Unresectable, metastatic Gastric Cancer
• Unresectable, metastatic Gastroesophageal Junction Cancer