Change In Diaphragmatic Thickness Predicts Extubation Success

Terminated

• Conditions: Mechanical Ventilation Complication
• Interventions: Procedure: Diaphragm Ultrasound

• Registration Number: NCT02656199
• Lead Sponsor: Albert Einstein Healthcare Network

Brief Summary

We will investigate whether measurement of the change in thickness of the diaphragm during the respiratory cycle by ultrasound can predict extubation success in a 48 hour window. We will also asses whether this is only possible on low levels of pressure support as has been shown previously, or if this technique retains its predictive power at higher levels of pressure support.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01
• Status Verified: 2016-01
• Study First Submitted: 2016-01-13
• Study First Submitted QC: 2016-01-13
• Study First Posted: 2016-01-14
• Primary Completion: 2017-01-13
• Study Completion: 2017-01-13
• Results First Submitted: 2020-02-24
• Results First Submitted QC: 2020-02-24
• Last Update Submitted: 2020-02-24
• Results First Posted: 2020-03-09
• Last Update Posted: 2020-03-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

• age greater than 18, ventilated for >24 hours

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Exclusion Criteria

• already chronically on mechanical ventilatory support, already has tracheostomy, has pathology that obscures visualization of the right hemidiaphragm, has acute stroke either hemorrhagic or ischemic, cannot identify appropriate decision maker to get informed consent.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Main Cohort	Diaphragm Ultrasound	all patients enrolled will have an ultrasound of their diaphragm performed once they are on a pressure support trial. Intervention: Diaphragm Ultrasound

Primary Outcome Measures

Name	Time	Method
Extubation Success	48 hours	Discontinuation from mechanical ventilation in 48 hours from ultrasound; PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.

Secondary Outcome Measures

Name	Time	Method
Re-intubation	48 hours from removal of ventilatory support	Reinstitution of mechanical ventilation within 48 hours of extubation PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.

Trial Locations

Locations (1)

Einstein Medical Center; 🇺🇸 Philadelphia, Pennsylvania, United States