ReadMap: Reading in Stroke Alexia and Typical Aging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aphasia
- Sponsor
- Georgetown University
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.
Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)
Time Frame: Collected within 1 month of behavioral testing
Part of MRI sequence that measures deep grey matter structure.
DTI (Diffusion Tensor Imaging)
Time Frame: Collected within 1 month of behavioral testing
Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.
Behavioral testing
Time Frame: Collected within 1 month of MRI
Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.