ReadMap: Reading in Stroke Alexia and Typical Aging

Recruiting

• Conditions: Aphasia; Stroke; Alexia

• Registration Number: NCT06700005
• Lead Sponsor: Georgetown University

Brief Summary

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.

Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-12
• Status Verified: 2024-10
• Study First Submitted: 2024-11-06
• Study First Submitted QC: 2024-11-18
• Last Update Submitted: 2024-11-18
• Study First Posted: 2024-11-21
• Last Update Posted: 2024-11-21
• Primary Completion: 2028-08-31
• Study Completion: 2028-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)	Collected within 1 month of behavioral testing	Part of MRI sequence that measures deep grey matter structure.
DTI (Diffusion Tensor Imaging)	Collected within 1 month of behavioral testing	Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.
Behavioral testing	Collected within 1 month of MRI	Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

Trial Locations

Locations (1)

Georgetown University Medical Center; 🇺🇸 Washington, District of Columbia, United States