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Clinical Trials/NCT06700005
NCT06700005
Recruiting
Not Applicable

ReadMap: Reading in Stroke Alexia and Typical Aging

Georgetown University1 site in 1 country300 target enrollmentJanuary 12, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Aphasia
Sponsor
Georgetown University
Enrollment
300
Locations
1
Primary Endpoint
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.

Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

Registry
clinicaltrials.gov
Start Date
January 12, 2023
End Date
August 31, 2028
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)

Time Frame: Collected within 1 month of behavioral testing

Part of MRI sequence that measures deep grey matter structure.

DTI (Diffusion Tensor Imaging)

Time Frame: Collected within 1 month of behavioral testing

Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.

Behavioral testing

Time Frame: Collected within 1 month of MRI

Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

Study Sites (1)

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