Is THERE a RELATIONSHIP BETWEEN PERIODONTAL CONDITION and ASPROSIN LEVEL in GINGIVAL CREVICULAR FLUID?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Asprosin level
研究概览
简要总结
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis and periodontitis.
详细描述
This study is investigating the level of asprosin hormone in gingival crevicular fluid of patients with periodontal diseases such as gingivitis and periodontitis, and observing the healthy patient in terms of the hormone levels, as well. 75 volunteer patients aged 18-45 years old were included in this study. These patients were divided equally to three groups: Group I; periodontal health, Group II; gingivitis, Group III; periodontitis.The body fluids including serum, saliva and gingival crevicular fluid were collected from this participants according to the proper protocol and their storage was provided under certain conditions. ELISA tests for asprosin and Tumour necrosis factor alpha were made in laboratory. Also, clinical measurements such as plaque index, bleeding on probing, probing pocket depth were recorded at first visit day of the participants. The data were analysed according to the different periodontal conditions, and correlated with asprosin hormone and tumour necrosis factor alpha level in gingival crevicular fluid, serum and saliva.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Those with any systemic disease
- •Individuals who take medication regularly
- •Pregnant or lactating women
- •Individuals with menopause and anthropause
- •Those who have undergone any periodontal treatment in the last six months
结局指标
主要结局
Asprosin level
时间窗: Day 1
Asprosin level (ng/mL) in gingival crevicular fluid, serum and saliva.
次要结局
- TNF-alpha levels(Day 1)
- Plaque index(Day 1)
- bleeding on probing(Day 1)
- probing pocket depth(Day 1)
- body mass index(Day 1)
研究者
Osman Fatih Arpag
Principal investigator
Mustafa Kemal University