Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications
- Conditions
- Depression
- Registration Number
- NCT01681407
- Lead Sponsor
- HaEmek Medical Center, Israel
- Brief Summary
A pilot study of mapping the peripheral plasma micro-RNA and proteomics patterns in depressive patients, treated with SSRI medications. It is an observational clinical bio-markers laboratory controlled research with no device.
The research includes two groups; one for patients diagnosed of having depression, and will get a standard SSRI medication regimen. Second group is for control subjects without depression. An option for a third group is planned to include first degree relatives of the depressed patients. After giving their informed consents, subjects and patients will go through standard clinical psychiatric interview, and routine clinical lab tests. Clinical standard, specific depression and anxiety questionnaires will be held at four follow-up meetings: at start; after 2 weeks; 4 weeks; and 10 weeks. Subjects and patients will be asked to give blood samples at these points of time for the lab processing: Complete plasma proteomics and specific micro-RNA levels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 17
- Depressed patients,over 18 yo
- Untreated with SSRI, in the last 3 months
- Bipolar patients or another major psychopathology
- Depressive disorder clearly due to general medical condition, or drug related
- BMI under 18.5 or above 40
- Pregnant patients
- Active suicidality
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depressive symptoms remission or response rates, under usual SSRI treatment. 10 weeks of follow up
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
HaEmek Medical Center
🇮🇱Afula, Israel