The Effect of the Nature And Frequency of a Stimulation on the Amplitude of the Temporal Summation of Pain
试验速览
- 阶段
- 不适用
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Temporal Summation of Pain - repetitive mechanical stimulation
研究概览
简要总结
Temporal summation is a mechanism that enhances pain perception. It is a natural mechanism present in most individuals. Generally, temporal summation is measured by the application of a moderately painful stimulation for several seconds.However, there is still no official recommendation in the literature. There is therefore a great disparity in the protocols. Some studies apply thermal stimulation (heating the skin) while others apply mechanical stimulation (applying pressure). Another point of contention is that some studies apply continuous stimulation for 2 minutes while others apply a series of several small stimulation of 1 second). Between these studies, the amplitude of temporal summation varies according to the stimulation performed. Note also that the study population is also very different between studies. In these conditions, it remains difficult to know the impact of the nature of the stimulation on the measured amplitude of the temporal summation.
详细描述
Objective
To determine the effect of the nature and frequency of the stimulation used to measure one of the physiological mechanisms of pain
Methods: In order to meet the objective, 34 pain-free participants will be recruited (17 females and 17 males) between the ages of 18 and 30 years. A single visit will be proposed (approximately 1 h). Each participant will be stimulated with 4 stimulation conditions:
- continuous thermal (1 stimulation of two minutes)
- repetitive thermal (30 stimulations of 1 second)
- continuous mechanical (1 stimulation of two minutes)
- repetitive mechanical (30 stimulation of 1 second) In order to control certain psychological parameters, questionnaires measuring anxiety, depression and fear of pain will be administered. This will allow the investigation team to perform subgroup analyses if necessary. A repeated measures analysis of variance will be performed to meet the objective.
Anticipated Results: The objective of this project is to determine the impact of different stimuli on the measurement of a pain mechanism. In this sense, the results will be important since they will allow to develop recommendations to optimize the measurement of this mechanism.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects aged 18 to 30 years, able to consent (understand English or French)
- •No chronic pain
- •No primary sensory disorders
排除标准
- •Presence of upper extremity injuries
- •Absence of anxiety symptoms (HADs Score < 6) (Appendix 1)
- •Presence of cardiovascular disease / neurocognitive disorders / mental illness
- •Pregnant or postpartum women less than one year old
结局指标
主要结局
Temporal Summation of Pain - repetitive mechanical stimulation
时间窗: During stimulation
Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.
Temporal Summation of Pain - continuous thermal stimulation
时间窗: During stimulation
Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.
Temporal Summation of Pain - repetitive thermal stimulation
时间窗: During stimulation
Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.
Temporal Summation of Pain - continuous mechanical stimulation
时间窗: During stimulation
Temporal Summation of pain referred to the change of pain perception during a painful stimulation. Temporal summation will be calculated by the difference in pain perception (on a 0-100 scale) and the beginning and at the end of each stimulation sequence. Temporal summation will be express as a percentage of increased.
次要结局
未报告次要终点