Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain

Not Applicable

Completed

• Conditions: Gynecological Disorder
• Interventions: Other: The difference of the timing of rocuronium administration after propofol injection

• Registration Number: NCT04547608
• Lead Sponsor: Wonkwang University Hospital

Brief Summary

Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals. This study aimed to determine the impact of the timing of rocuronium after induction with propofol on temporal summation of pain in gynecologic laparoscopic surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-01
• Primary Completion: 2020-05-30
• Status Verified: 2020-09
• Study Completion: 2020-09-04
• Study First Submitted: 2020-09-07
• Study First Submitted QC: 2020-09-07
• Last Update Submitted: 2020-09-11
• Study First Posted: 2020-09-14
• Last Update Posted: 2020-09-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Elective gynecologic laparoscopic surgery
• American Society of Anesthesiologists' physical status class) I-II

Exclusion Criteria

• Menopause (to exclude the hormonal effect on pain)
• Patients who had muscular, cardiovascular, hepatic or kidney disorders and patients with a history of medication who would affect muscle relaxants were excluded from this study.
• Patients with difficult venous access on forearm, a known allergy to propofol or rocuronium, chronic pain, pregnancy, and those who had received analgesics or sedatives within the previous 24 hours, were excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group PRi	The difference of the timing of rocuronium administration after propofol injection	received immediate injection of rocuronium after propofol administration,
group PRd	The difference of the timing of rocuronium administration after propofol injection	rocuronium injection when bispectral index score became below 60 after propofol administration

Primary Outcome Measures

Name	Time	Method
the grade of rocuronium induced withdrawal movement.	during anesthesia induction	withdrawal movements were graded by the investigator according to the following scale: 1. - no pain (no response); 2. - mild pain (movement at wrist only); 3. - moderate pain (movement involving the arm only with elbow or shoulder); 4. - severe pain (generalized response or movement in more than one extremity

Secondary Outcome Measures

Name	Time	Method
visual analog scale (VAS) for injection pain	during anesthesia induction	check VAS for pain after propofol administration. visual analog scale with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain
VAS for pain	at 1 hour, 24 hours and 48 hours	check VAS with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain
Patient controlled analgesia (PCA) Opioid consumption	at 24 and 48 hours	check the volume of PCA Opioid consumption (ml) (PCA) pump containing fentanyl (800 ug), ketorolac (150 mg), and ramosetron (0.6 mg) in a total volume of 150 mL of saline was set to deliver a basal infusion of 2 mL/h and bolus doses of 0.5 mL, with a 15-min lockout period for postoperative analgesia.

Trial Locations

Locations (1)

WonwangUH; 🇰🇷 Iksan, Jeonbuk, Korea, Republic of