Evaluation of Complete Median Nerve Transection With Clinical, Electroneuromyographic and Diffusion Tensor Imaging
- Conditions
- Wound, Healed (Morphologic Abnormality)Injury of Median Nerve
- Registration Number
- NCT02672631
- Lead Sponsor
- TC Erciyes University
- Brief Summary
The aim of this study is to determine whether clinical, sensory and motor development correlated with the values obtained from Electroneuromyography and DTI in postoperative follow up patients who underwent primary repair after the total median nerve injuries.
Median nerve is one of three major nerves of hand and forearm and often injure with glass etc, in follow up of healing; clinical examination and ENMG are often used. Both of these methods are subjective, noninvasive and objective new method is required. In this context; differences between intact, recovering and not healed nerve tissue's diffusions have led to the hypothesis; "The recovery of the repaired nerve tissue can be monitored by Diffusion Tensor Imaging method".
- Detailed Description
The aim of this study is to determine whether clinical, sensory and motor development correlated with the values obtained from Electroneuromyography and DTI in postoperative follow up patients who underwent primary repair after the total median nerve injuries.
Median nerve is one of three major nerves of hand and forearm. It is below flexor tendon and retinaculum at the level of the wrist and often injured at this level and subtotally. The primary microsurgical suture technique under a microscope is the gold standard treatment. In follow up of healing; clinical examination and ENMG are often used. Both of these methods are subjective, although ENMG is more objective, however that is an invasive method, and need experienced neurologists. So, noninvasive and objective new method is required. In this context; differences between intact, recovering and not healed nerve tissue's diffusions have led to the hypothesis; "The recovery of the repaired nerve tissue can be monitored by Diffusion Tensor Imaging method". There is no similar study in the literature.
Ten patients who were operated for median nerve injuries in 2014 will be enrolled. In the sample, correlations between Tinnel Test, motor strength assessment (Medical Research Council (MRC) Scale), static two-point discrimination test (S2PD), Semmes-Weinstein (SW) monofilament test, the Disability of the Arm, Shoulder and Hand (DASH) test, EMG with the DTI results will be assessed.
At the end of the study; it is expected that a significant correlation between conventional methods and DTI. If the results support the hypothesis; DTI may get to the literature as noninvasive and objective method in follow of nerve regeneration.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- 18 - 40 years old
- Total and isolated median nerve transection
- Under 18 and over 40 years old
- Partially transection of median nerve
- Median nerve transection with radial or ulnar nerve injury
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Physical Examination 2 months conventional evaluation of nerve healing. That Evaluate sensitivity, motor functions and paresthesia
Electroneuromyography 2 months conventional evaluation of nerve healing - That evaluate axonal transfer speed etc
- Secondary Outcome Measures
Name Time Method Diffusion Tensor Imaging Methods 2 months new method for evaluation of nerve healing with tissues diffusion on magnetic resonants imaging
Trial Locations
- Locations (1)
Erciyes University Faculty of Medicine
🇹🇷Melikgazi, Kayseri, Turkey
Erciyes University Faculty of Medicine🇹🇷Melikgazi, Kayseri, TurkeyAli Eray GUNAY, resisdentContact+905556493401alieraygunay@hotmail.comİbrahim KARAMAN, docentContact05327183353drikaraman@gmail.comAhmet Güney, DocentPrincipal InvestigatorMithat Öner, DocentPrincipal InvestigatorSerap DoğanPrincipal InvestigatorMehmet Fatih YetkinPrincipal InvestigatorAli Eray Günay, residentPrincipal Investigator