NL-OMON20480招募中不适用
ANTIBIOTIC EXPOSURE AT THE INFECTION SITE IN PERIPROSTHETIC JOINT INFECTIONS
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Erasmus MC
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Age = 18 years.
- •-Written informed consent has been obtained from the patient
- •-Suffering from periprosthetic (hip or knee) joint infections and therefore treated with one of the following antibiotics as part of the two-stage arthroplasty exchange:
- •oIV: vancomycin, flucloxacillin or cefuroxime
- •oOral: flucloxacillin, clindamycin or co-trimoxazole
- •-Patients undergoing a two-stage implant exchange of hip or knee with or without antibiotic free interval prior to re-implantation.
- •-Able and willing to undergo joint punctures and venous blood sampling during and, in case of an antibiotic free interval, at the end of the six-weeks antibiotic treatment.
排除标准
- •-Unable to draw samples for study purposes.
- •-Language barriers.
- •-The use of the target antibiotics at the start of study participation (and therefore at the start of the antibiotic treatment as part of the two-stage arthroplasty exchange).
- •-The use of drugs interacting with the target antibiotics.
研究者
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