NCT05329558Enrolling By Invitation不适用
Pilot Study: Local and Systemic Changes in Osteonecrosis of the Jawbone
Medical University of Graz1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2018年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- target gene expression
研究概览
简要总结
Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years or older
- •with/without ART
- •with/without MRONJ
排除标准
- •smoker (>10 cigarettes/day)
- •pregnancy
结局指标
主要结局
target gene expression
时间窗: through study completion, an average of 1 year
differences in gene expression recorded by qPCR will be assessed
次要结局
未报告次要终点
研究者
Foessl, Ines, MSc
Investigator
Medical University of Graz
研究点 (1)
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