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Clinical Trials/NCT05329558
NCT05329558
Enrolling By Invitation
Not Applicable

Pilot Study: Local and Systemic Changes in Osteonecrosis of the Jawbone

Medical University of Graz1 site in 1 country100 target enrollmentMarch 1, 2018
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ConditionsOsteonecrosis of the Jaw

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Osteonecrosis of the Jaw
Sponsor
Medical University of Graz
Enrollment
100
Locations
1
Primary Endpoint
target gene expression
Status
Enrolling By Invitation
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.

Registry
clinicaltrials.gov
Start Date
March 1, 2018
End Date
December 1, 2026
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Medical University of Graz
Responsible Party
Principal Investigator
Principal Investigator

Foessl, Ines, MSc

Investigator

Medical University of Graz

Eligibility Criteria

Inclusion Criteria

  • •18 years or older
  • •with/without ART
  • •with/without MRONJ

Exclusion Criteria

  • •smoker (\>10 cigarettes/day)
  • •pregnancy

Outcomes

Primary Outcomes

target gene expression

Time Frame: through study completion, an average of 1 year

differences in gene expression recorded by qPCR will be assessed

Study Sites (1)

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