NCT01130389
Completed
Not Applicable
Trans-PBRN Case-control Study of Osteonecrosis of the Jaws
Dental Practice-Based Research Network5 sites in 1 country309 target enrollmentJanuary 2007
ConditionsOsteonecrosis of the Jaw
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Osteonecrosis of the Jaw
- Sponsor
- Dental Practice-Based Research Network
- Enrollment
- 309
- Locations
- 5
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study was to examine risk factors for osteonecrosis of the jaw (ONJ), including the possible association with bisphosphonates (BPs). This study used the research infrastructure from the three NIDCR-funded dental practice-based research networks (DPBRN, PEARL, PRECEDENT). De-identified data from the DPBRN were merged with comparable de-identified data from PEARL and PRECEDENT to form a single trans-PBRN data set used for analysis.
Detailed Description
The aims of this study were to (1) test the hypothesis that (BP) treatment is a risk factor for (ONJ); (2) to test the hypothesis that dental diseases (particularly periodontal disease), and invasive dental procedures such as dental extractions are true risk factors for (ONJ).
Investigators
Eligibility Criteria
Inclusion Criteria
- •participants directly involved in this study were patients of dentists from the dental practice based research networks (DPBRN, PEARL, PRECEDENT).
Exclusion Criteria
- •participants with a history of sickle cell anemia
- •participants with a history of external severe trauma to the jaws
Outcomes
Primary Outcomes
Not specified
Study Sites (5)
Loading locations...
Similar Trials
Completed
Not Applicable
Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic CancerBone DiseasesMetastasesOsteonecrosisBisphosphonate-Associated Osteonecrosis of the JawNCT01325142University of Michigan271
Unknown
Not Applicable
Risk factors of osteonecrosis of the jaw in patients with multiple myeloma receiving IV bisphosphonatesPatients diagnosed with multiple myeloma and had received intravenous bisphosphonates.Risk factor, Multiple myeloma, Intravenous bisphosphonateTCTR20230206007Chulalongkorn University120
Enrolling By Invitation
Not Applicable
Local and Systemic Changes in Osteonecrosis of the JawboneOsteonecrosis of the JawNCT05329558Medical University of Graz100
Completed
Not Applicable
Osteonecrosis of the Jaw (ONJ) and Infection Among Nordic Cancer Patients Treated With XGEVA™ or Zoledronic AcidOsteonecrosis of the JawInfection Leading to HospitalizationNCT01967160Amgen2,560
Recruiting
Not Applicable
Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive DrugsOsteonecrosis of the JawOsteonecrosis Due to Drugs, JawOsteonecrosis Due to DrugBisphosphonate-Associated OsteonecrosisBisphosphonate-Associated Osteonecrosis of the JawNCT06457776Catholic University of the Sacred Heart126