Clinical outcomes of adjunctive antimicrobial photodynamic therapy in the treatment of patients with severe chronic periodontitis - a controlled randomized clinical trial

Not Applicable

Conditions: severe chronic periodontitis
K05.3
Chronic periodontitis

Registration Number: DRKS00005389

Lead Sponsor: Danube Private University (DPU)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 45

Inclusion Criteria

age of 30–70 years
- present diagnosis of severe chronic periodontitis of at least 6 teeth with a probing pocket depth (PPD) >5 mm, bleeding
- written informed consent
- Plaque Index (PI) < 1 and Gingiva Index (GI) <1 after pretreatment

Exclusion Criteria

- major systemic illnesses (i.e., diabetes mellitus, cancer, HIV, tuberculosis, bone metabolic diseases or disorders that compromise wound healing, rheumatoid arthritis, lupus erythematosus)
- radiation, or immunosuppressive therapy
- pregnant or breastfeeding woman
- smoking behaviour
- use of long-term administration of anti-inflammatory medications
- antibiotic therapies in the previous 6 months
- teeth with furcation involvement
- radiologically diagnosted combined endodontic-periodontic lesions

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
probing pocket depth, measured with computer administrated probe (Florida-Probe) at baseline, as well as 3, 6 and 12 months after therapy

Secondary Outcome Measures

Name	Time	Method
Bleeding on Probing (number of sites with bleeding after Probing) measured with computer adnmistraded probe at baseline, 3, 6 and 12 months after therapy, periodontopathogenic bacteria measured with a chairside test at baseline, 2 weeks, 6 and 12 months after therapy, inflammatory markers from gingival cevicular fluid<br><br>