Study of Administration of Tranexamic Acid or Placebo on Bleeding in Adult Patients in Surgery for Liver Transplantatio

Not Applicable

• Conditions: Coagulopathy; Liver cells carcinoma; K74.6; C15.378.100.220; C22.0

• Registration Number: RBR-3jwv5kh
• Lead Sponsor: Hospital de Clinicas de Porto Alegre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-27
• Last Update Posted: 29 May 2023
• Study Completion: 2023-05-31

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Only adult ASA III to IV patients, 18 to 70 years old, scheduled for liver transplantation at the Hospital de Clínicas de Porto Alegre, Santa Casa de Porto Alegre and Hospital das Clínicas Faculty of Medicine University of São Paulo.

Exclusion Criteria

Patients with a history of acute arterial thrombosis or venous thromboembolism (<1 month), patients with a history of known thrombophilia, Budd-Chiari syndrome, primary biliary cholangitis, primary sclerosing cholangitis, patients with reduced left ventricular function ( ejection fraction <40%), pulmonary hypertension, preoperative pulmonary edema, or severe preoperative hemodynamic changes requiring the use of vasoactive drugs, planned use of tranexamic acid systemically during surgery, hypersensitivity or known allergy to acid tranexamic, history of seizure disorder, patients who have recently suffered a stroke or myocardial infarction (<1 month), patients with subarachnoid hemorrhage in the last 30 days and patients previously undergoing cranial neurosurgery. Patients with chronic dialysis kidney disease or patients in need of a liver-kidney transplant will also be excluded from the study.

Study & Design

• Study Type: Intervention
• Study Design: Not specified