Computer-based Training of Face Recollection to Improve Face Recognition in Developmental Prosopagnosia

Not Applicable

Recruiting

• Conditions: Developmental Prosopagnosia

• Registration Number: NCT04799340
• Lead Sponsor: Boston VA Research Institute, Inc.

Brief Summary

This study will examine the effectiveness of a cognitive training intervention targeting face recollection, repetition lag training, at improving face recognition in Developmental Prosopagnosia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-11
• Study First Submitted QC: 2021-03-11
• Study Start: 2021-03-12
• Study First Posted: 2021-03-16
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-23
• Last Update Posted: 2022-11-29
• Primary Completion: 2025-05-31
• Study Completion: 2025-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Developmental prosopagnosic participants will be included if they are...

• aged 18-90,
• have lifelong histories of face recognition difficulties that impact their everyday life (i.e., not associated with some event such as a stroke, seizure, etc)
• score significantly below the mean on the famous faces test and Cambridge Face Memory Test

Exclusion Criteria

Participants will be excluded from the study if they...

• have a history of a significant neurological disorder including hydrocephalus, stroke, moderate to severe traumatic brain injury (TBI), severe neuromuscular diseases, or severe hypoxia due to cardiac arrest.
• have impairments that interfere with cognitive performance, such as uncorrected hearing or vision, lack of English proficiency, musculoskeletal or other issues
• have psychiatric disorders, such as schizophrenia, major depressive disorder, bipolar disorder, chronic intractable obsessive-compulsive disorder, or agoraphobia.
• We will exclude individuals who are currently dependent on alcohol or other substances, as this may negatively impact cognitive performance.
• We will exclude participants who currently are, or within the last 6 months, participating in a behavioral or pharmacological intervention.
• Patients with a history of mild TBI or simple concussion will not be excluded as long as it was > 6 months ago and as long as they have not had repeated concussions (>5)
• We will include individuals with a diagnosis of ADHD as long as their medication has been consistent for the past 6 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Face Perception	30 minutes	composite of face matching tasks, Cambridge Face perception Test and computerized Benton, higher score is better
Face Recollection	15 minutes	old/new face recognition test, extracting familiarity and recollection parameters, higher score is better
Cambridge Face Memory Test	15 minutes	learning and recognizing novel faces, out of 72 (higher score is better)

Secondary Outcome Measures

Name	Time	Method
Face-name learning task	15 minutes
Self-reported face recognition	5 minutes	questionnaire

Trial Locations

Locations (1)

VA Boston Healthcare System, 150 S. Huntington Ave.; 🇺🇸 Boston, Massachusetts, United States