Computerized Cognitive Training for Patients With Epilepsy

Not Applicable

Withdrawn

• Conditions: Epilepsy
• Interventions: Behavioral: Luminosity Trial Memory Match; Behavioral: Luminosity Trial Memory Matrix; Behavioral: Luminosity Trial Famliar Faces; Behavioral: Luminosity Trial Brain Shift; Behavioral: Luminosity Trial Star Search; Behavioral: Luminosity Trial Word Bubbles; Behavioral: Luminosity Trial Color Match; Behavioral: Luminosity Trial Ebb and Flow; Behavioral: Luminosity TrialChalk Board Challenge; Behavioral: Luminosiuty Follow that Frog; Behavioral: Luminosity Train of Thought

• Registration Number: NCT03644082
• Lead Sponsor: NYU Langone Health

Brief Summary

This is a study on the effectiveness of computerized cognitive training for treatment of memory disorders in patients with epilepsy. Participants will be recruited from patients referred for neuropsychological assessment through the NYU Comprehensive Epilepsy Center's inpatient and outpatient services. Individuals meeting inclusion criteria will be screened for the presence of memory disturbance (defined by results of neuropsychological testing) and lack of exposure to any previous form of computerized cognitive training. All eligible subjects will be provided with an account for Lumosity with instructions to complete training modules 5 days per week for a total of 8 consecutive weeks. Outcomes will be evaluated through changes on the neuropsychological test battery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-08-21
• Study First Submitted QC: 2018-08-21
• Study First Posted: 2018-08-23
• Study Start: 2020-12
• Primary Completion: 2021-04-30
• Study Completion: 2021-04-30
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-29
• Last Update Posted: 2021-07-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
• Presence of memory disturbance, as defined by an immediate or delayed memory index score < 85 on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
• Availability of a home computer and internet for access to the computer training program.

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Exclusion Criteria

• Full Scale IQ < 80, as assessed by an appropriate Wechsler scale (WAIS-IV or WASI-II).
• Epilepsy surgery within 8 weeks of the beginning of the trial.
• History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Alzheimer's disease, multiple sclerosis, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
• History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia or bipolar disorder). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
• Visual or auditory impairment, which precludes participation in part, or all of the testing or computer training.
• English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for >10 years.
• Previous exposure (> one week) to Lumosity or a similar computerized training program.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Epilepsy Patients	Luminosity Trial Word Bubbles	-
Epilepsy Patients	Luminosity Trial Famliar Faces	-
Epilepsy Patients	Luminosity Trial Brain Shift	-
Epilepsy Patients	Luminosity Trial Color Match	-
Epilepsy Patients	Luminosity Trial Ebb and Flow	-
Epilepsy Patients	Luminosity TrialChalk Board Challenge	-
Epilepsy Patients	Luminosiuty Follow that Frog	-
Epilepsy Patients	Luminosity Trial Memory Match	-
Epilepsy Patients	Luminosity Trial Memory Matrix	-
Epilepsy Patients	Luminosity Trial Star Search	-
Epilepsy Patients	Luminosity Train of Thought	-

Primary Outcome Measures

Name	Time	Method
Immediate Memory Index Score	12 Months	Score on the Repeatable Battery for the Assessment of Neuro-psychological Status (RBANS) will be used to measure immediate memory
Delayed Memory Index Score	12 Months	Score on the Repeatable Battery for the Assessment of Neuro-psychological Status (RBANS) will be used to measure immediate memory

Trial Locations

Locations (1)

New York University School of Medicine; 🇺🇸 New York, New York, United States