Effect of tizanidine on pain after cardiac surgery

Phase 3

Not yet recruiting

Conditions: Coronary Artery Disease.
Chapter IX / Diseases of the circulatory system (100-199) / 120 Angina pectoris/ 121 Acute myocardial infarction
120/ 121

Registration Number: IRCT20201220049774N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients hospitalized for CABG surgery in the age range of 18 to 65 years receiving standard medication regimen (Aspirin, P2Y12 platelet receptor blockers, angiotensin-converting enzyme inhibitors, beta-blockers, and statins)
Signing the informed consent form by the patient

Exclusion Criteria

severe renal failure (CrCl <25 ml/min)
Severe hepatic impairment (patients with class C hepatic impairment based on Child-Pugh classification with a score of 10-15 based on the parameters of ascites, bilirubin, albumin, INR and encephalopathy)
History of hypersensitivity reactions to tizanidine
History of drug or alcohol addiction
Low arterial blood pressure (SBP <90 mmHg or MAP <65 mmHg)
Concomitant use of dexmedetomidine
Chronic pain
Taking painkillers 24 hours before surgery
Neuromuscular disease
Class IV (severe) heart failure according to the New York Heart Association classification
Receiving ciprofloxacin during hospitalization
Pregnancy or breastfeeding

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The severity of postoperative pain with the use of Numerical Rating Scale. Timepoint: The severity of postoperative pain is measured in the intensive care unit after the end of surgery and on days first and second postoperative, two hours after the administration of 4 mg tizanidine tablet. Method of measurement: Numerical Rating Scale.

Secondary Outcome Measures