IRCT20201220049774N1尚未招募3 期
Evaluation of the effect of tizanidine administration on acute pain control after CABG in adult patients: A randomized placebo-controlled clinical trial
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •Patients hospitalized for CABG surgery in the age range of 18 to 65 years receiving standard medication regimen (Aspirin, P2Y12 platelet receptor blockers, angiotensin-converting enzyme inhibitors, beta-blockers, and statins)
- •Signing the informed consent form by the patient
排除标准
- •severe renal failure (CrCl <25 ml/min)
- •Severe hepatic impairment (patients with class C hepatic impairment based on Child-Pugh classification with a score of 10-15 based on the parameters of ascites, bilirubin, albumin, INR and encephalopathy)
- •History of hypersensitivity reactions to tizanidine
- •History of drug or alcohol addiction
- •Low arterial blood pressure (SBP <90 mmHg or MAP <65 mmHg)
- •Concomitant use of dexmedetomidine
- •Chronic pain
- •Taking painkillers 24 hours before surgery
- •Neuromuscular disease
- •Class IV (severe) heart failure according to the New York Heart Association classification
- •Receiving ciprofloxacin during hospitalization
- •Pregnancy or breastfeeding
研究者
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