Acute Effect of Resistance Training With Different Intensity on Circulating Levels of Neurotrophic Growth Factors and Homocysteine in Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 12
- 主要终点
- BDNF
研究概览
简要总结
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:
- Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.
- whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.
Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).
Researchers will compare the training effects of two different training on these growth factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age between 18 to 30 years
- •no experiencing musculoskeletal disorders or sports injuries
- •had not participated any regular aerobic endurance or resistance training with in the previous half years
- •no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
- •good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)
排除标准
- •experiencing musculoskeletal disorders or sports injuries in recent 1 month
- •had regular resistance training exercise
- •intake any supplementary(drug and hormone)
结局指标
主要结局
BDNF
时间窗: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
IGF-1
时间窗: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
Irisin
时间窗: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
Hcy
时间窗: "0 minutes" "60 minutes" "90 minutes"
homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction
Rata of perceived exertion
时间窗: "0 minutes" "60 minutes" "90 minutes"
The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.
VEGF
时间窗: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
Blood lactate
时间窗: "0 minutes" "60 minutes" "90 minutes"
serum blood lactate
次要结局
- Accuracy rate("0 minutes" "60 minutes" "90 minutes")
- Reactive time("0 minutes" "60 minutes" "90 minutes")
研究者
Chongwen Zuo
Doctoral
Air Force Military Medical University, China