Analgesic efficacy of Transversus abdominis plance block : Ultrasono-guided method vs. Laparoscopic guided method.

Not Applicable

Completed

• Conditions: Not Applicable

• Registration Number: KCT0001576
• Lead Sponsor: Kyungpook National University Medical Center

Brief Summary

A prospective, randomized, single-blinded non-inferiority clinical trial was conducted with patients undergoing elective laparoscopic colectomy for colon cancer. Eighty patients were randomly assigned (1:1 ratio) to the UTAP and LTAP groups. At the end of the operation, opioid consumption and numeric rating scores (NRS; 0 [no pain] to 10 [worst pain]) of pain were recorded at 2, 6, 24, and 48 hours postoperatively and were compared between the groups. The primary end point was pain NRS during rest at 24 hours after operation. Thirty-eight patients in the LTAP group and 35 patients in the UTAP group completed the study protocol. We found no significant difference in mean ± SD pain NRS during rest at 24 hours between the LTAP group (3.90 ± 1.7) and the UTAP group (4.5 ± 1.9). The mean difference in pain NRS during rest at 24 hours was 0.57 (95% CI -0.26 to 1.41). Because the lower boundary of a 95% CI for the differences in pain NRS was > -1, non-inferiority was established. There was no significant difference between the groups in NRS pain during rest, NRS pain on movement, and postoperative morphine consumption during the 48 hours after operation. These results show our new LTAP block technique was non-inferior to the ultrasound-guided technique in providing a TAP block after laparoscopic colorectal operation.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

We recruit colorectal cancer patients who aged 20-75 year-old and are scheduled to undergo elective laparoscopic colectomy under general anesthesia.

Exclusion Criteria

Patients who have a history of allergy to systemic opioids, drug use disorder, chronic pain syndrome, chronic obstructive pulomonary disorder and those who taking analgesics within 24h before surgery are excluded from this study.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Pain

Secondary Outcome Measures

Name	Time	Method
Postoperative morphine consumption, Postoperative nausea and vomitting, Quality of Recovery-15 questionnaire (QOR-15)