Investigating the role of dopamine in healthy and pathological gambling: A pharmaco-fMRI study

Recruiting

• Conditions: Pathological gambling; gambling addiction; 10021563

• Registration Number: NL-OMON36024
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

All groups: males volunteers between 18 and 55 years of age, predominant right-handedness
Pathological gambling group: *active* pathological gamblers, as assessed by a score >= 5 on the SOGS questionnaire and the presence of 5 or more DSM-IV criteria for the diagnosis of pathological gambling
Control group: score <= 1 on SOGS questionnaire and none of DSM-IV criteria for pathological gambling

Exclusion Criteria

- neurological disorders
- DSM-IV axis I psychiatric disorders other than pathological gambling / nicotine dependence
- current psychiatric treatment
- heart problems
- claustrophobia
- metallic implants
(See p. 14 on the research protocol for more details)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Blood Oxygenation Level Dependent (BOLD) signal as measured with functional<br /><br>magnetic resonance imaging (fMRI)<br /><br>- Behavioral performance on computerized tasks<br /><br>- Psychophysiological recordings, e.g., electrodermal activity, blood pressure,<br /><br>heart rate and eye tracking</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Subjective measurements ,e.g., self-report questionnaires, visual analogue<br /><br>scales<br /><br>- Blood plasma levels of prolactin and sulpiride</p><br>