The effects of increased levels of dopamine on the activation in the dopaminergic system.
Completed
- Conditions
- n.v.t.10009841
- Registration Number
- NL-OMON33408
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Good health, right-handedness, male, between 23 and 35 years of age, no history of mental illnesses or neurological disorders, no history of drug or alcohol abuse, no use of medication.
Exclusion Criteria
MRI contra-indications, such as claustrophobia and metal parts in the body, cardiovascular abnormalities as assessed by standard 12-lead electrocardiogram (ECG), excessive drinking and hypertension.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) Regional cerebral blood flow (method: arterial spin labeling MRI) during<br /><br>resting state in the cortex, sub cortical and brain stem regions.<br /><br>2) Regional blood oxygenated level dependent (BOLD) response (method: BOLD<br /><br>functional MRI) during resting state and during task performance, in the<br /><br>cortex, sub cortical and brain stem regions.<br /><br>3) Task performance; the number of correct response and the reaction time.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1) The levels of Ritalinic acid in the blood<br /><br>2) Mood and physical complaints (method: questionnaire)<br /><br>3) Hart and breathing rate (assessed during the scan session)</p><br>