Dopaminergic modulation of neuronal response to a stimulus-reward task in people with 22q11 deletion syndrome and healthy volunteers: a functional MRI study.
- Conditions
- delusionpsychosis10013511
- Registration Number
- NL-OMON29870
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
20 individuals with 22q11 deletion syndrome with no psychiatric history and no use of psychiatric medication, age 18 till 50 years.
20 healthy volunteers, matched for age and gender, with no psychiatric history and no use of psychiatric medication.
Exclusion Criteria
Pregnancy, presence of metals that are not allowed in MRI-investigation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Blood oxygen level dependent (BOLD) contrast measured during a modified<br /><br>reversal learning task within the MRI scanner. </p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Level of catecholamine synthesis, measured by blood levels of:<br /><br>* homovanillic acid (HVA)<br /><br>* 3-methoxy-4 hydroxyphenethyleneglycol (MHPG),<br /><br>* VMA<br /><br>* prolactine<br /><br><br /><br>and urine levels of:<br /><br>* HVA<br /><br>* MHPG<br /><br>* VMA<br /><br>* dopamine (free and conjungated) and norepinephrine (free and conjungated)<br /><br><br /><br>2. Score on modified reversal learning taak<br /><br>3. Possible extrapyramidal side-effects<br /><br>4. Subjective experiences<br /><br>5. Depressive and positive and negative symptoms </p><br>