The effects of increased levels of dopamine on the activation in the dopaminergic system.
- Conditions
- Disorders related to disturbed dopaminergic functioning.
- Registration Number
- NL-OMON28941
- Lead Sponsor
- Maastircht University
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Healthy, right handed, male, between 23 and 35 years of age;
2. No history of mental illness or neurological disorders;
Exclusion Criteria
1. MRI contra-indications, such as claustrophobia and metal parts in the body;
2. Cardiovascular abnormalities as assessed by standard 12-lead electrocardiogram (ECG);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Regional cerebral blood flow (method: arterial spin labeling MRI) during resting state in the cortex, sub cortical and brain stem regions;<br /><br>2. Regional blood oxygenated level dependent (BOLD) response (method: BOLD functional MRI) during resting state and during task performance, in the cortex, sub cortical and brain stem regions;<br /> <br>3) Task performance: the number of correct response and the reaction time.<br>
- Secondary Outcome Measures
Name Time Method 1. The levels of Ritalinic acid in the blood;<br /><br>2. Mood and physical complaints (method: questionnaire);<br /><br>3. Hart and breathing rate (assessed during the scan session).<br>