The dopaminergic system in patients with Functional Dyspepsia analyzed by an Alpha-Methyl-Para-Tyrosine (AMPT) challenge test and Single Photon Emission Computed Tomography (SPECT) imaging before and after treatment with amitriptyline.
- Conditions
- Functional Dyspepsia (FD)
- Registration Number
- NL-OMON20110
- Lead Sponsor
- Academic Medical Center (AMC) amsterdam, department of gastroenterology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. Age 18-65 years;
2. Functional dyspepsia (NDI>25);
3. Take part in the amitriptyline study;
4. No effect of PPI or 3 months constantly the same doses;
5. No depression (ZUNG<50);
6. No medications which influence the intestine.
Exclusion Criteria
1. Gastroduodenal surgery;
2. Reflux-like dyspepsia (Rome II criteria);
3. Use of antidepressivants;
4. Organic abnormalities;
5. Pregnancy;
6. Severe cardiac, renal, pulmonary, hepatic or systemic diseases. Hyperthyroidism, glaucoma and epilepsy;
7. Metal implantates.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate if patients with functional dyspepsia have a change in their dopaminergic system what leads to visceral hypersensitivity.
- Secondary Outcome Measures
Name Time Method Has amitriptyline a positive effect on those changes in the dopaminergic system through reducing the stress?