The dopaminergic system in patients with functional dyspepsia analyzed by an alpha-methyl-para-tyrosine (AMPT) challenge test and single photon emission computed tomography (SPECT) imaging before and after treatment with amitriptyline

Completed

• Conditions: Functional dyspepsia (FD); Dyspepsia; Digestive System

• Registration Number: ISRCTN63226989
• Lead Sponsor: Academic Medical Center (AMC), Department of Gastroenterology (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-06-07
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Age 18-65 years
2. Functional dyspepsia (Nepean dyspepsia index [NDI] >25)
3. Take part in the amitriptyline study (ISRCTN76116512)
4. No effect on proton pump inhibitor (PPI), or a constant three-month dosage of PPI
5. No depression (Zung self-rating depression scale <50)
6. No medications which influence the intestine

Exclusion Criteria

1. Gastroduodenal surgery
2. Reflux-like dyspepsia (Rome II criteria)
3. Use of antidepressants
4. Organic abnormalities
5. Pregnancy
6. Severe cardiac, renal, pulmonary, hepatic or systemic diseases, hyperthyroidism, glaucoma and epilepsy
7. Metal implants

Study & Design

• Study Type: Interventional
• Study Design: Not specified