Mapping dopaminergic function using pharmacologic Magnetic Resonance Imaging (phMRI)
- Conditions
- not applicablekinder en jeugd psychiatrie
- Registration Number
- NL-OMON33010
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Healthy male adult volunteers, aged between 20 and 35.
Exclusion Criteria
Contraindications for MRI (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia. Symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma, hypersensitivity or idiosyncrasy to sympathomimetic amines, agitation, and history of drug abuse, or use of psychotropic drugs that affect DA function, such as methylphenidate and cocaine (anamnestic). Finally, cardial conduction disorder (abnormal ECG) en renal disease (serum creatinine * 110 mmol/L).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>BOLD: % change in BOLD SI from baseline (ROI)<br /><br>PWI: % change in ratio from baseline (ROI: rCBV/white matter rCBV)<br /><br>ASL: % change in CBF from baseline (ROI CBF/100 mg tissue)<br /><br>SPECT: DAT ratio (striatal ROI binding/binding in cerebellum)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Amphetamine Interview Rating Scale</p><br>