Mapping dopaminergic function using phMRI in healthy volunteers and amphetamine users
Completed
- Conditions
- kinder en jeugd psychatrieaddictionSubstance dependence
- Registration Number
- NL-OMON37495
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Healty male volunteers, aged between 18 and 30 years. Use of amphetamine on at least 40 occasions in the past year in group of amphetamine users.
Exclusion Criteria
Contraindications for MRI (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia. Symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, glaucoma, hypersensitivity or idiosyncrasy to sympathomimetic amines, agitation, and history of drug abuse, or use of psychotropic drugs that affect DA function, such as methylphenidate and cocaine (anamnestic). Finally, cardial conduction disorder (abnormal ECG) en renal disease.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>BOLD: % change in BOLD signal intensity from baseline (ROI)<br /><br>ASL: % change in CBF from baseline (ROI CBF/100 mg tissue)<br /><br>SPECT: difference in binding ratio between baseline and after d-AMPH<br /><br>administration (striatal ROI binding/binding in occipital cortex)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Visual analogue rating scale (VAS)<br /><br>Outcome measures of neuropsychological tests: Stroop Word Colour Test (STROOP),<br /><br>Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test (TMT), Iowa<br /><br>Gambling Task (IGT), Digit Span test, Tower of London Test, Emotional Go-NoGo<br /><br>Task, Attention Network Task</p><br>