Dopamine receptor imaging after dopamine depletion in adults who are at ultra high risk for psychosis, and in healthy volunteers: a (123I)IBZM SPECT study

Conditions: psychosis
10039628
delusion

Registration Number: NL-OMON30735

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

a) 40 patients:
- age 18 till 35 years
- ultra high risk criteria for development of psychosis, as defined by McGorry et al. (2002)
Healthy controls:
- Matched for age, sex, ethnicity and IQ

Exclusion Criteria

- previous psychotic episode for more than one week
- previous use of antipsychotics, amphetamine or cocaine
- medical disorder affecting brain function e.g. epilepsy
- participation in investigations with radio-activity in the last year
- pregnancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome measure will be the difference in (123I)IBZM striatal dopamine<br /><br>(D2) binding between the control scan and the scan with acute dopamine<br /><br>depletion with AMPT.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Level of catecholamin synthesis, measured by blood levels of:<br /><br>- homovanillin acid (HVA)<br /><br>- 3-methoxy-4-hydroxyphenethyleneglycol (MHPG)<br /><br>- prolactin<br /><br><br /><br>and urine levels of:<br /><br>- HVA<br /><br>- MHPG<br /><br>- dopamin (free and conjugated) en norepinephrin (free and conjugated)<br /><br><br /><br>2. Possible extrapyramidal side-effects<br /><br>3. Subjective experiences<br /><br>4. Depressive and positive and negative symptoms<br /><br>5. Pre pulse inhibition (PPI): a non-invasive electrophysiological measurement<br /><br>during 12 minutes. The eye blink reflex will be measured while the person<br /><br>listens to beep tones with a headphone.</p><br>