Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT01517425
- Lead Sponsor
- Scripps Translational Science Institute
- Brief Summary
This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Cases:
- Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry
- Eligible to have their blood drawn
- Be reliable, cooperative and willing to comply with all protocol-specified procedures
- Able to understand and grant informed consent
Controls:
- Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort
- Eligible to have their blood drawn
- Be reliable, cooperative and willing to comply with all protocol-specified procedures
- Able to understand and grant informed consent
Exclusion Criteria
- Unwilling or unable to grant informed consent.
- Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method iPSC development five years Develop methods of iPSC generation from patients with genomic risk.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Scripps Translational Science Institute
🇺🇸La Jolla, California, United States