Stress Sensitivity and Reward Responsivity: An Integration of Two Endophenotypes in Major Depression
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depressed
- Sponsor
- Dr. Kate Harkness
- Enrollment
- 219
- Locations
- 1
- Primary Endpoint
- Stress Sensitivity: Salivary Hormone and Stress Challenge Test (TSST)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.
Detailed Description
Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner. Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.
Investigators
Dr. Kate Harkness
Dr.
Queen's University
Eligibility Criteria
Inclusion Criteria
- •Outpatients aged 18-65
- •Currently suffering from unipolar depression
- •Fluency in English, sufficient to complete the interviews and self-report questionnaires
Exclusion Criteria
- •Clinical diagnosis of bipolar disorder, psychotic disorders, current alcohol/substance dependence, or significant medical comorbidity
- •Treatment-resistant (defined as failing more than 3 trials of anti-depressant medication)
- •History of neurological insult (e.g., concussion), neurological disease, seizure disorder
- •Pregnant women
- •Endocrine disorders
- •High suicidal risk, defined by clinician judgement
- •For Healthy Control Participants:
- •Inclusion Criteria:
- •Adults aged 18-65
- •No history of Axis I disorders according to DSM-IV-TR criteria, as determined by the SCID
Outcomes
Primary Outcomes
Stress Sensitivity: Salivary Hormone and Stress Challenge Test (TSST)
Time Frame: 2 hours after beginning of Time B Appointment
Participants are required to give a speech and an arithmetic test in front of a panel. Saliva samples are collected at 8 points throughout the test.
Secondary Outcomes
- Mood and Anxiety Symptom Questionnaire (MASQ)(Administered at first baseline appointment and covers past 2 weeks)
- Snaith Hamilton Pleasure Scale (SHAPS and SHAPS-C)(Administered at first baseline appointment and covers past 2 weeks prior to interview)
- Reward Responsivity: Probabilistic Reward Task(Administered at second baseline appointment)