Study of Effects of Repetitive Transcranial Magnetic Stimulation on cognition of Refractory Obsessive Compulsive Disorder Patients
- Conditions
- refractory obsessive compulsive disorder.Mixed obsessional thoughts and acts
- Registration Number
- IRCT2014110419808N1
- Lead Sponsor
- Hamadan University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria: have a DSM-IV-TR diagnosis of OCD; ages between 18 and 65 years old; have failed to achieve a clinical response, or did not tolerate, at least 3 separate antidepressant trials of sufficient dose (included clomipramine) and CBT for at least 10 weeks; score of greater than or equal to 17 on the Y-BOCS.
a history of DSM-IV-TR substance dependence in the last 6 months or DSM-IV-TR substance abuse in the last month; a concomitant major unstable medical or neurologic illness or have had a history of seizures; acutely suicidal; being pregnant; metal implants; if they are currently (or in the last 4 weeks) taking more than lorazepam 2 mg daily (or equivalent), monoamine oxidase inhibitors, and/or bupropion (due to its associated increased risk for seizures); Education lower than 2nd class of guidance school
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of cognition in refractory OCD. Timepoint: after 10th, 20th sessions of rTMS or sham. Method of measurement: PASSAT, Digit symbol, Digit Span.
- Secondary Outcome Measures
Name Time Method