Effects of Combined Tracheal Suctioning and Expiratory Pause 5 or 10 Seconds: a Crossover Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 4
- 主要终点
- Weight of secretion aspirated (grams)
研究概览
简要总结
A randomized crossover clinical trial conducted in an Intensive Care Unit of the Hospital de Clinicas de Porto Alegre (HCPA) to compare the efficacy of the two techniques on the amount of aspirated pulmonary secretion and pulmonary mechanics: aspiration of the closed system following an expiratory pause with mechanical ventilator for 5 seconds (5-Second Expiratory Pause) and aspiration of the closed system following an expiratory pause with mechanical ventilator for 10 seconds (10-Second Expiratory Pause).
详细描述
After randomization, all patients will be positioned in dorsal decubitus with the head elevated at 30 degrees and will be aspirated once with a closed suction system and with a vacuum of -40cm H2O. Hemodynamic and pulmonary parameters will be collected and recorded. One of the two techniques will be applied, according to randomization, and the outcomes measured. After two hours, hemodynamic and pulmonary parameters will be re-collected, and the second technique will be applied. The outcomes will be measured again.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients in 24 and 72 hours of mechanical ventilation.
- •Patients with closed aspiration system.
- •Patients hemodynamically stable (mean arterial blood pressure ≥ 60 mmHg and with dose of Noradrenaline ≤ 1μg/kg/minute).
排除标准
- •Undrained pneumothorax and hemothorax.
- •Subcutaneous emphysema.
- •Patients who refuse to participate in the study.
结局指标
主要结局
Weight of secretion aspirated (grams)
时间窗: Immediately after the application of one of the closed system aspiration techniques.
The secretion aspirated into the collection flask will be weighed on a precision laboratory scale.
次要结局
- Peripheral arterial oxygen saturation (SpO2) (%)(One minute after the application of the studied technique.)
- Peak inspiratory pressure (PIP) (cm H2O)(One minute after the application of the studied technique.)
- End expiratory pressure (PEEP) (cmH2O)(One minute after the application of the studied technique.)
- Air trapping (AUTO-PEEP) (cmH2O)(One minute after the application of the studied technique.)
- Mechanical ventilation circuit pressure (cmH2O)(One minute after the application of the studied technique.)
- Tidal volume (TV) (ml)(One minute after the application of the studied technique.)
- Endotracheal tube diameter (ETT) (mm)(One minute after the application of the studied technique.)
- Dynamic compliance (Cd) (ml/cmH2O)(One minute after the application of the studied technique.)
- Resistance (R) (L/s)(One minute after the application of the studied technique.)
- Drive pressure (cmH2O)(One minute after the application of the studied technique.)
- Heart rate (HR) (beats per minute)(One minute after the application of the studied technique.)
- Respiratory rate (RR) (breaths per minute).(One minute after the application of the studied technique.)
- Mean arterial pressure (MAP) (mmHg)(One minute after the application of the studied technique.)